Introducing Good Clean Rx: A New Approach to Microbiome-Informed Vaginal Care

Vaginal health is rarely a one-variable problem. Recurrent bacterial vaginosis, recurrent or complicated vulvovaginal candidiasis, vulvovaginal pain, genitourinary syndrome of menopause, cancer-related vaginal symptoms, and other complex conditions can persist despite repeated empiric treatment.

When symptoms persist or recur, clinicians often need more information to understand what may be contributing and to choose the most appropriate treatment strategy.

That’s why we created Good Clean Rx: to give healthcare professionals a more complete clinical toolkit, combining quantitative vaginal microbiome testing, evidence-informed treatment protocols, and custom-compounded prescription therapies within one accessible prescriber platform.

BiomeNourish™: A Prescription Base Designed for Vaginal Physiology

At the foundation of Good Clean Rx is BiomeNourish™, a prescription compounding base developed specifically for vulvovaginal use.

Building on more than 20 years of Good Clean Love’s vaginal health formulation experience and patented Bio-Match® technology, BiomeNourish™ was developed with vaginal physiology in mind. Its formulation considers factors including pH, osmolality, tissue compatibility, and microbial ecology rather than simply adapting a generic pharmaceutical vehicle for vaginal use.

The BiomeNourish™ cream is formulated within an acidic pH range associated with a healthy, Lactobacillus-dominant vaginal environment, with controlled osmolality and a preservation system selected with vaginal tissue and microbiome compatibility in mind. The suppository uses a fatty base that melts at body temperature and incorporates a proprietary prebiotic ingredient designed to support the vaginal environment.

The goal is straightforward: the vehicle matters. Prescription therapies are delivered in a base designed specifically for vulvovaginal use, with vaginal physiology considered alongside the active pharmaceutical ingredient.

Move Beyond Positive-or-Negative Vaginitis Testing

Within the Good Clean Rx platform, providers have access to a 56-target vaginal microbiome qPCR panel that provides quantitative information across protective Lactobacillus species, BV-associated organisms, bacterial and fungal pathogens, uropathogens, and select sexually transmitted infections.

Quantitative testing provides additional context about the vaginal microbial environment. Results can help clinicians characterize Lactobacillus dominance or microbial disruption, detect and quantify organisms included on the panel, and establish a baseline that can be followed over time.

When interpreted alongside symptoms, examination, medical history, and other diagnostic findings, this information can help clinicians better understand complex or recurrent presentations and inform treatment decisions. Species-level information may also be useful when organism identification influences management, such as recurrent or non-albicans Candida infections.

One Platform. More Clinical Options.

Good Clean Rx brings testing, clinical information, prescription therapies, and fulfillment into a single workflow.

Through the prescriber portal, healthcare professionals can:

• Order 56-target vaginal microbiome panels directly for patients

• Review quantitative results and clinical interpretation

• Follow results longitudinally when clinically appropriate

• Browse a formulary by condition or therapeutic category

• Prescribe established formulations or request customized compounded therapies

• Have prescriptions fulfilled and shipped directly to patients

The formulary includes options such as targeted antimicrobials, low-dose hormonal therapies, neuropathic pain modulators, anti-inflammatory agents, barrier and moisture support, and topical anesthetics.

Built for Complex Vulvovaginal Care

Good Clean Rx is designed to support clinicians managing:

• Recurrent bacterial vaginosis

• Recurrent or complicated vulvovaginal candidiasis

• Vulvodynia and vestibulodynia

• Genitourinary syndrome of menopause

• Vulvovaginal symptoms in cancer survivors

• Lichen sclerosus and other inflammatory vulvar dermatoses

• Pain-predominant conditions requiring multimodal care

• Recurrent UTI where vaginal microbial ecology may be clinically relevant

• Vaginal microbiome disruption following infection, antimicrobial treatment, hormonal change, or other interventions

These patients often need more than another round of the same treatment. Good Clean Rx gives providers additional clinical information, broader prescription options, and vulvovaginal-specific formulations to support a more individualized treatment strategy.

Bringing Microbiome Science into Prescription Care

For more than two decades, Good Clean Love has focused on vaginal health, formulation science, and the microbiome. Good Clean Rx extends that foundation into clinician-directed prescription care.

The result is a practical clinical platform built around three things: better information, purpose-built formulations, and more treatment options.

Become a Good Clean Rx prescriber: goodcleanclinicalcare.com/for-providers